| Date & Time | Favorite | Line | Underdog | Total |
| 9/5 8:30 ET | At Denver | -8.5 | Baltimore | 48.5 |
| 9/8 1:00 ET | New England | -9.5 | At Buffalo | 50 |
| 9/8 1:00 ET | At Pittsburgh | -7 | Tennessee | 42 |
| 9/8 1:00 ET | At New Orleans | -3 | Atlanta | 54 |
| 9/8 1:00 ET | Tampa Bay | -3 | At NY Jets | 39.5 |
| 9/8 1:00 ET | Kansas City | -3.5 | At Jacksonville | 41 |
| 9/8 1:00 ET | At Chicago | -3 | Cincinnati | 42 |
| 9/8 1:00 ET | At Cleveland | PK | Miami | 41 |
| 9/8 1:00 ET | Seattle | -3 | At Carolina | 45 |
| 9/8 1:00 ET | At Detroit | -4.5 | Minnesota | 46.5 |
| 9/8 1:00 ET | At Indianapolis | -9.5 | Oakland | 47 |
| 9/8 4:25 ET | At St. Louis | -5 | Arizona | 41 |
| 9/8 4:25 ET | At San Francisco | -4.5 | Green Bay | 49 |
| 9/8 8:30 ET | At Dallas | -3 | NY Giants | 48.5 |
| 9/9 7:10 ET | At Washington | -3.5 | Philadelphia | 51 |
| 9/9 10:20 ET | Houston | -3.5 | At San Diego | 44 |
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